PRALUENT is taken every 2 weeks or 4 weeks (monthly)

Your doctor will decide which dose of PRALUENT is right for you. Dosage may vary depending on your diagnosis. Use PRALUENT as prescribed by your doctor.

Instructions for Use — Pen 75 mg

Instructions for Use — Pen 150 mg

OR

Note: If you have been prescribed 300 mg once monthly, please utilize the

Instructions for Use — Pen 150 mg

Learn how to inject PRALUENT

You or your caregiver should receive training on the right way to prepare and administer PRALUENT. Do not try to inject PRALUENT until you have been shown the right way by your healthcare provider or nurse.

Watch the video below

Getting ready for your injection

Remember to store PRALUENT in your refrigerator until you're ready to use it. Once you take it out, it takes between 30 and 40 minutes to reach room temperature and be ready for injection. PRALUENT may be left out at room temperature up to 77°F (25°C) for a maximum of 30 days in its original carton to protect it from light. After PRALUENT is removed from the refrigerator, it must be used within 30 days or thrown away.

Before you start your injection, you will need:

The PRALUENT pen

1 alcohol wipe

1 cotton ball or gauze pad

A sharps disposal container

Keep PRALUENT and all medicines out of the reach of children.

For self-injecting the monthly 300-mg dose, prepare two 150-mg pens.

The instructions below apply to both the 75-mg and the 150-mg pens

Step 1

Look at the label

• Check that you have the correct product and the correct dose
• Check the expiration date: do not use if this date has passed
• DO NOT use the pen if it has been dropped or damaged

Step 2

Look at the window

• Check to make sure the liquid is clear, colorless to pale yellow, and free from particles (see picture). If it is not, do not use
• You may see an air bubble. This is normal
• DO NOT use if the window appears solid yellow (see picture)

Step 3

Bring to room temperature for 30-40 minutes

• Take PRALUENT out of the refrigerator to warm up before using
  • For monthly 300-mg dosing, let two 150-mg pens come to room temperature
• DO NOT heat the pen; let it warm up on its own
• DO NOT expose the pen to direct sunlight
• You may want to set a timer for 30 to 40 minutes to remind you when PRALUENT has reached room temperature and is ready to be injected
• DO NOT put the pen back in the refrigerator

If needed, patients may keep PRALUENT at room temperature up to 77°F (25°C) for a maximum of 30 days in its original carton to protect it from light. DO NOT store above 77°F (25°C). After PRALUENT is removed from the refrigerator, it must be used within 30 days or thrown away.

Step 4

Prepare the injection site

• Injection sites:
  • Top of thigh
  • Belly (except for the 2-inch area around your navel)
  • Outer side of your upper arms (for caregivers)

• Wash your hands with soap and water and dry with a towel
• Clean skin in the injection area with an alcohol wipe
• DO NOT use on skin that is injured, tender, hard, red, or hot
• DO NOT use any areas with visible veins, scars, or stretch marks
• Change your injection site each time you give yourself an injection. If you need to use the same injection site, make sure it is not the same spot you used last time
• Reminder: Use a different injection site for the second injection of the monthly 300-mg dose

How to inject

The instructions below apply to both the 75-mg pen and the 150-mg pen

Step 1

Pull off the blue needle cap

DO NOT touch the yellow safety needle cover

• DO NOT pull off the blue needle cap until you are ready to inject
• DO NOT use the pen if the blue needle cap is missing or not securely attached
• DO NOT put the blue needle cap back on

Step 2

Hold your PRALUENT pen upright, with the yellow safety needle cover at the bottom, so that you can see the window

Your thumb should not touch the green button yet

• DO NOT shake the pen
• DO NOT touch the yellow safety needle cover
• Make sure the inspection window is facing you and that you can see it

Step 3

Press the yellow safety needle cover down onto your skin

• Press the yellow safety needle cover straight down onto your skin at roughly a 90° angle
• DO NOT lift the pen from your skin
• Use the same pressure for the entire injection
• If needed, pinch the skin to make sure the injection site is firm
  • It is important to keep the skin pinched while injecting

DO NOT touch the green button yet

DO NOT touch the green button yet

• Firmly press down until the yellow safety needle cover disappears into the pen and is no longer visible

• Firmly press down until the yellow safety needle cover disappears into the pen and is no longer visible

The pen will not work if the yellow safety needle cover is not pushed all the way down

Step 4

Push and immediately release the green button

• Continue to firmly press down so that the yellow safety needle cover is not visible
• You will hear a "click." Your injection has now started
• Immediately let go of the green button
• The window will start to turn yellow

Step 5

Hold pen in place against your skin until the entire window is yellow

• Use the same pressure for the entire injection
• The injection may take up to 20 seconds

Step 6

Check that the window has turned yellow before removing the pen

• DO NOT remove the pen until the entire window has turned yellow
• You may hear a second “click” when the injection is complete
• If the window does not turn completely yellow, do not give yourself a second dose without speaking to your doctor, pharmacist, or nurse

Step 7

Lift pen away from your skin

• DO NOT rub the skin after the injection
• If you see any blood, press a cotton ball or gauze on the site until the bleeding stops

Step 8

Throw away pen and blue needle cap in sharps disposal container

• DO NOT put the blue needle cap back on
• Throw away pen and blue needle cap in a sharps disposal container right after use
• For the monthly 300-mg dose, throw out the first 150-mg pen before repeating the steps for your second injection
• Always keep the container out of the sight and reach of children
• DO NOT reuse the pen

When self-injecting the monthly 300-mg dose, repeat ALL steps with a second 150-mg pen at a different injection site

• Put your used pens in a sharps disposal container right after use. DO NOT throw away pens and caps in your household trash
• If you do not have an FDA-cleared sharps disposal container, you may use a household container that:
  • is made of a heavy-duty plastic;
  • can be closed with a tight-fitting, puncture-resistant lid to prevent sharp objects from being able to come out;
  • is upright and stable during use;
  • is leak resistant; and
  • is properly labeled to warn of hazardous waste inside the container
• DO NOT dispose of your used sharps disposal container in your household trash unless your community guidelines permit this
• DO NOT recycle your used sharps disposal container
• Always keep your sharps disposal container out of the sight and reach of children
• For more information about sharps disposal in the state that you live in, go to the FDA’s website

Important things to know and to keep in mind when self-injecting with PRALUENT:

1. Have the Instructions for Use at hand as a reference for information on the right way to prepare and give the PRALUENT injections at home with the easy-to-use pre-filled pen
2. You can make PRALUENT part of your routine
   1. Store PRALUENT in your refrigerator until you’re ready to use it
   2. PRALUENT should be allowed to warm to room temperature for 30 to 40 minutes before use. An easy way to do this is to take it out of the refrigerator while you’re eating breakfast or dinner. It will be warm enough to inject after you’re done eating
   3. If needed, patients may keep PRALUENT at room temperature up to 77°F (25°C) for a maximum of 30 days in its original carton to protect it from light. DO NOT store above 77°F (25°C). After PRALUENT is removed from the refrigerator, it must be used within 30 days or thrown away
3. You can choose what site to inject (see below)
   1. PRALUENT is given by injection under your skin (subcutaneously) once every 2 weeks or 4 weeks (monthly dosing option). If your healthcare provider prescribes you the monthly dose, you will give yourself 2 separate injections in a row, using a different pen for each injection and 2 different injection sites
   2. You can inject PRALUENT into the following sites: your thigh, the back of your upper arm (generally given by a care provider), or your stomach
   3. DO NOT use PRALUENT within 2 inches of your belly button; or where the skin is injured, tender, hard, red, hot, scarred, or any area where there are visible veins, scars, or stretch marks
   4. Choose a different spot each time you inject (for example, right thigh then left thigh, or right side of stomach then left side of stomach)
   5. If you take other self-injection medications, choose a different area to inject PRALUENT

What if you miss a dose?

• If you forget to use PRALUENT or are not able to take the dose at your regular time, inject your missed dose as soon as you remember, within 7 days.

• If you missed a dose by more than 7 days and you inject every 2 weeks, wait until your next scheduled dose to restart PRALUENT or, if you inject every 4 weeks, start a new schedule from the time you remember to take your dose
• If you are not sure when to restart PRALUENT, ask your healthcare provider or pharmacist

Need another resource? Download and print the official PRALUENT Instructions for Use here:

Instructions for 75-mg penInstructions for 150-mg pen

Hear from Gina, an actual patient, about her experience with the PRALUENT pen

Watch the video below